Article

Genetic background sets the trajectory of cancer evolution

2025-01-15

Abstract excerpt

Human cancers are heterogeneous. Their genomes evolve from genetically diverse germlines in complex and dynamic environments, including exposure to potential carcinogens. This heterogeneity of humans, our environmental exposures, and subsequent tumours makes it challenging to understand the extent to which cancer evolution is predictable. Addressing this limitation, we re-ran early tumour evolution hundreds of tim...

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Literature Corpus work: 942a7184-38e9-5abb-9e40-e2554946215d
DOI: 10.1101/2025.01.13.632787

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