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Article

Mitochondrial DNA variation and cancer.

Nature reviews. Cancer - 1 Jul 2021

Kopinski Piotr K, Singh Larry N, Zhang Shiping, Lott Marie T, Wallace Douglas C

Abstract excerpt

Variation in the mitochondrial DNA (mtDNA) sequence is common in certain tumours. Two classes of cancer mtDNA variants can be identified: de novo mutations that act as 'inducers' of carcinogenesis and functional variants that act as 'adaptors', permitting cancer cells to thrive in different environments. These mtDNA variants have three origins: inherited variants, which run in families, somatic mutations arising...

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Identifiers

PMID: 34045735
DOI: 10.1038/s41568-021-00358-w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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