Article
Unraveling bidirectional evolution of unstable mitochondrial DNA mutations in hepatocellular carcinoma at single-cell resolution.
Hepatology (Baltimore, Md.) - 1 Jul 2025
Zhou Kaixiang, Wang Zhenni, Guo Wenjie, Xie Fanfan, Yuan Qing, Guo Shanshan, Zhang Huanqin, Liu Yang, Gu Xiwen, Song Wenjie, Guo Xu, Xing Jinliang
Abstract excerpt
BACKGROUND AND AIMS: Somatic mutations in mitochondrial DNA (mtDNA) are abundant in HCC and directly affect metabolic homeostasis and tumor progression. The mixed population of mutant and wild-type mtDNA alleles within a cell, termed heteroplasmy, can vary from cell-to-cell and orchestrate tumorigenesis. However, the systematic evolutionary dynamics of somatic mtDNA mutations in HCC tissues remain to be...
Read the complete abstract on PubMedTopics
- Carcinoma, Hepatocellular
- Liver Neoplasms
- Humans
- DNA, Mitochondrial
- Mutation
- Animals