Article
Mitochondrial DNA is a major source of driver mutations in cancer.
Trends in cancer - 1 Dec 2022
Kim Minsoo, Mahmood Mahnoor, Reznik Ed, Gammage Payam A
Abstract excerpt
Mitochondrial DNA (mtDNA) mutations are among the most common genetic events in all tumors and directly impact metabolic homeostasis. Despite the central role mitochondria play in energy metabolism and cellular physiology, the role of mutations in the mitochondrial genomes of tumors has been contentious. Until recently, genomic and functional studies of mtDNA variants were impeded by a lack of adequate tumor...
Topics
- Humans
- DNA, Mitochondrial
- Mitochondria
- Neoplasms
- Genome, Mitochondrial
- Mutation