Article

Mutational landscape of a chemically-induced mouse model of liver cancer

2018-01-04

Abstract excerpt

Carcinogen-induced mouse models of liver cancer are used extensively to study the pathogenesis of the disease and have a critical role in validating candidate therapeutics. These models can recapitulate molecular and histological features of human disease. However, it is not known if the spectra of genomic alterations driving these mouse tumour genomes are comparable to those found in humans. Here, we provide a de...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6f7de4ca-3430-5a93-9ee7-952b6738e31e
DOI: 10.1101/242891

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mutational landscape of a chemically-induced mouse model of liver cancerDOI 10.1101/242891Read

Mutational landscape of a chemically-induced mouse model of liver cancer.Semantic proximity Read

Genomic and transcriptomic analyses of chemical hepatocarcinogenesis aggravated by oncoprotein lossSemantic proximity Read

Exome Sequencing of Fresh-frozen or Formalin-fixed Paraffin-embedded B6C3F1/N Mouse Hepatocellular Carcinomas Arising Either Spontaneously or due to Chronic Chemical Exposure.Semantic proximity Read

The mutational landscapes of genetic and chemical models of Kras-driven lung cancer.Semantic proximity Read

Integrative genomic analysis of mouse and human hepatocellular carcinomaSemantic proximity Read

Genomic landscape of carcinogen-induced and genetically induced mouse skin squamous cell carcinoma.Semantic proximity Read

Germline and somatic variation influence nuclear-mitochondrial crosstalk in tumourigenesisSemantic proximity Read

Human-correlated genetic HCC models identify combination therapy for precision medicineSemantic proximity Read

Chronic liver injury alters driver mutation profiles in hepatocellular carcinoma in mice.Semantic proximity Read

Mutational signatures reveal the dynamic interplay of risk factors and cellular processes during liver tumorigenesis.Semantic proximity Read

Mutational signatures and processes in hepatobiliary cancers.Semantic proximity Read

Genomic sequencing identifies a few mutations driving the independent origin of primary liver tumors in a chronic hepatitis murine model.Semantic proximity Read