Article

Chromatin conformation capture (Hi-C) sequencing of patient-derived xenografts: analysis guidelines

2020-10-17

Abstract excerpt

Sequencing of patient-derived xenograft (PDX) mouse models allows investigation of the molecular mechanisms of human tumor samples engrafted in a mouse host. Thus, both human and mouse genetic material is sequenced. Several methods have been developed to remove mouse sequencing reads from RNA-seq or exome sequencing PDX data and improve the downstream signal. However, for more recent chromatin conformation capture...

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Identifiers and source

Literature Corpus work: 03394a26-9363-5c62-81f9-5feb8726e083
DOI: 10.1101/2020.10.17.343814

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