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XenofilteR: computational deconvolution of mouse and human reads in tumor xenograft sequence data

4 Oct 2018

Abstract excerpt

BACKGROUND: Mouse xenografts from (patient-derived) tumors (PDX) or tumor cell lines are widely used as models to study various biological and preclinical aspects of cancer. However, analyses of their RNA and DNA profiles are challenging, because they comprise reads not only from the grafted human cancer but also from the murine host. The reads of murine origin result in false positives in mutation analysis of...

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PMID: 30286710
DOI: 10.1186/s12859-018-2353-5

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