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Assessment of patient-derived tumour xenografts (PDXs) as a discovery tool for cancer epigenomics

11 Dec 2014

Abstract excerpt

BACKGROUND: The use of tumour xenografts is a well-established research tool in cancer genomics but has not yet been comprehensively evaluated for cancer epigenomics. METHODS: In this study, we assessed the suitability of patient-derived tumour xenografts (PDXs) for methylome analysis using Infinium 450 K Beadchips and MeDIP-seq. RESULTS: Controlled for confounding host (mouse) sequences, comparison of primary...

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PMID: 25587359
DOI: 10.1186/s13073-014-0116-0

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