Article

Bioinformatics workflows for genomic analysis of tumors from Patient Derived Xenografts (PDX): challenges and guidelines

2018-09-12

Abstract excerpt

Bioinformatics workflows for analyzing genomic data obtained from xenografted tumor (e.g., human tumors engrafted in a mouse host) must address several challenges, including separating mouse and human sequence reads and accurate identification of somatic mutations and copy number aberrations when paired normal DNA from the patient is not available. We report here data analysis workflows that address these challeng...

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Literature Corpus work: 10b10ed6-56da-54ae-b44d-475b1a810c55
DOI: 10.1101/414946

Open publication

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