Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Representation of genomic intratumor heterogeneity in multi-region non-small cell lung cancer patient-derived xenograft models

31 May 2024

Abstract excerpt

Patient-derived xenograft (PDX) models are widely used in cancer research. To investigate the genomic fidelity of non-small cell lung cancer PDX models, we established 48 PDX models from 22 patients enrolled in the TRACERx study. Multi-region tumor sampling increased successful PDX engraftment and most models were histologically similar to their parent tumor. Whole-exome sequencing enabled comparison of tumors...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer Genomics and Diagnostics
Share to Lung Cancer Treatments and Mutations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38821942
DOI: 10.1038/s41467-024-47547-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Representation of genomic intratumor heterogeneity in multi-region non-small cell lung cancer patient-derived xenograft modelsPMID 38821942Read ↗

Genomic evolution of non-small cell lung cancer patient-derived xenograft modelsSemantic proximity Read ↗

Molecular heterogeneity of non-small cell lung carcinoma patient-derived xenografts closely reflect their primary tumors.Semantic proximity Read ↗

Next-Generation Sequence Analysis of Cancer Xenograft ModelsSemantic proximity Read ↗

Genomic data analysis workflows for tumors from patient-derived xenografts (PDXs): challenges and guidelinesSemantic proximity Read ↗

Tracking Genomic Cancer Evolution for Precision Medicine: The Lung TRACERx StudySemantic proximity Read ↗

Genetic Clonality as the Hallmark Driving Evolution of Non-Small Cell Lung CancerSemantic proximity Read ↗

A Lung Cancer Mouse Model DatabaseSemantic proximity Read ↗

Computational approach to discriminate human and mouse sequences in patient-derived tumour xenografts.Semantic proximity Read ↗

Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenograftsSemantic proximity Read ↗

Genomic and transcriptomic analysis of a library of small cell lung cancer patient-derived xenograftsSemantic proximity Read ↗

Genetic heterogeneity and clonal evolution during metastasis in breast cancer patient-derived tumor xenograft modelsSemantic proximity Read ↗

Polyclonal-Monoclonal Transition in Lung Squamous Cell Carcinoma EvolutionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.