Article

pdxBlacklist: Identifying artefactual variants in patient-derived xenograft samples

2017-08-25

Abstract excerpt

<h4>Summary</h4> Patient-derived tumor xenograft (PDX) samples typically represent a mixture of mouse and human tissue. Variant call sets derived from sequencing such samples are commonly contaminated with false positive variants that arise when mouse-derived reads are mapped to the human genome. pdxBlacklist is a novel approach designed to rapidly identify these false-positive variants, and thus significantly i...

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Literature Corpus work: 146e9214-1730-5c81-aaa8-3209e3c54682
DOI: 10.1101/180752

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