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Article

Impact of mouse contamination in genomic profiling of patient-derived models and best practice for robust analysis.

Genome biology - 11 Nov 2019

Jo Se-Young, Kim Eunyoung, Kim Sangwoo

Abstract excerpt

BACKGROUND: Patient-derived xenograft and cell line models are popular models for clinical cancer research. However, the inevitable inclusion of a mouse genome in a patient-derived model is a remaining concern in the analysis. Although multiple tools and filtering strategies have been developed to account for this, research has yet to demonstrate the exact impact of the mouse genome and the optimal use of these...

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PMID: 31707992
DOI: 10.1186/s13059-019-1849-2
PMCID: PMC6844030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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