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Article

Computational approach to discriminate human and mouse sequences in patient-derived tumour xenografts.

BMC genomics - 5 Jan 2018

Callari Maurizio, Batra Ankita Sati, Batra Rajbir Nath, Sammut Stephen-John, Greenwood Wendy, Clifford Harry, Hercus Colin, Chin Suet-Feung, Bruna Alejandra, Rueda Oscar M, Caldas Carlos

Abstract excerpt

BACKGROUND: Patient-Derived Tumour Xenografts (PDTXs) have emerged as the pre-clinical models that best represent clinical tumour diversity and intra-tumour heterogeneity. The molecular characterization of PDTXs using High-Throughput Sequencing (HTS) is essential; however, the presence of mouse stroma is challenging for HTS data analysis. Indeed, the high homology between the two genomes results in a proportion...

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Identifiers

PMID: 29304755
DOI: 10.1186/s12864-017-4414-y
PMCID: PMC5755132

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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