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Genomic data analysis workflows for tumors from patient-derived xenografts (PDXs): challenges and guidelines

1 Jul 2019

Abstract excerpt

BACKGROUND: Patient-derived xenograft (PDX) models are in vivo models of human cancer that have been used for translational cancer research and therapy selection for individual patients. The Jackson Laboratory (JAX) PDX resource comprises 455 models originating from 34 different primary sites (as of 05/08/2019). The models undergo rigorous quality control and are genomically characterized to identify somatic...

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PMID: 31262303
DOI: 10.1186/s12920-019-0551-2

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