Article

Sensitive and specific post-call filtering of genetic variants in xenograft and primary tumors

2017-09-12

Abstract excerpt

<h4>Motivation</h4> Tumor genome sequencing offers great promise for guiding research and therapy, but spurious variant calls can arise from multiple sources. Mouse contamination can generate many spurious calls when sequencing patient-derived xenografts (PDXs). Paralogous genome sequences can also generate spurious calls when sequencing any tumor. We developed a BLAST-based algorithm, MAPEX, to identify and filt...

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Literature Corpus work: 06dc3f25-c951-577a-b660-c0e891c029ee
DOI: 10.1101/187468

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