Article

Systematic Establishment of Robustness and Standards in Patient-Derived Xenograft Experiments and Analysis

2019-10-02

Abstract excerpt

Patient-Derived Xenografts (PDXs) are tumor-in-mouse models for cancer. PDX collections, such as those supported by the NCI PDXNet program, are powerful resources for preclinical therapeutic testing. However, variations in experimental design and analysis procedures have limited interpretability. To determine the robustness of PDX studies, the PDXNet tested temozolomide drug response for three pre-validated PDX mo...

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Literature Corpus work: 9c6dc391-5bc9-50d4-8fcb-30a1fa4c4a79
DOI: 10.1101/790246

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