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Article

Next-Generation Sequence Analysis of Cancer Xenograft Models

26 Sept 2013

Abstract excerpt

Next-generation sequencing (NGS) studies in cancer are limited by the amount, quality and purity of tissue samples. In this situation, primary xenografts have proven useful preclinical models. However, the presence of mouse-derived stromal cells represents a technical challenge to their use in NGS studies. We examined this problem in an established primary xenograft model of small cell lung cancer (SCLC), a...

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PMID: 24086345
DOI: 10.1371/journal.pone.0074432

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