Article

Structural variation detection by proximity ligation from FFPE tumor tissue

2018-02-15

Abstract excerpt

The clinical management and therapy of many solid tumor malignancies is dependent on detection of medically actionable or diagnostically relevant genetic variation. However, a principal challenge for genetic assays from tumors is the fragmented and chemically damaged state of DNA in formalin-fixed paraffin-embedded (FFPE) samples. From highly fragmented DNA and RNA there is no current technology for generating lon...

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Identifiers and source

Literature Corpus work: d01615dc-fa3a-5109-839d-d084bd01dfaf
DOI: 10.1101/266023

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