Domain 5 binds near a highly conserved dinucleotide in the joiner linking domains 2 and 3 of a group II intron.

Article

Domain 5 binds near a highly conserved dinucleotide in the joiner linking domains 2 and 3 of a group II intron.

RNA (New York, N.Y.) - 1 Feb 1998

Podar M, Zhuo J, Zhang M, Franzen J S, Perlman P S, Peebles C L

Abstract excerpt

Photocrosslinking has identified the joiner between domains 2 and 3 [J(23)] as folding near domain 5 (D5), a highly conserved helical substructure of group II introns required for both splicing reactions. D5 RNAs labeled with the photocrosslinker 4-thiouridine (4sU) reacted with highly conserved...

Topics

Base Sequence
Binding Sites
Conserved Sequence
Cross-Linking Reagents
DNA, Fungal
Genetic Variation
Introns
Molecular Sequence Data
Nucleic Acid Conformation
Photochemistry
RNA Splicing
RNA, Catalytic

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