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Article

Requirements of a group I intron for reactions at the 3' splice site.

Journal of molecular biology - 5 Feb 1993

van der Horst G, Inoue T

Abstract excerpt

Structural elements of the Tetrahymena group I intron have been implicated in directing the exon-ligation transesterification reaction (the second step of self-splicing) to the correct 3' splice site. The 3' splice site also serves as the reaction site in a distinct transesterification reaction known as G-exchange and in a specific hydrolysis reaction. The dependence of the reactions on the internal guide...

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Source

Identifiers

PMID: 8433366
DOI: 10.1006/jmbi.1993.1072

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Requirements of a group I intron for reactions at the 3' splice site.PMID 8433366Read ↗

Two universally conserved adenosines of the group I intron that are important for self-splicing but not for core catalytic activity.Semantic proximity Read ↗

A 3' splice site-binding sequence in the catalytic core of a group I intron.Semantic proximity Read ↗

Increased efficiency of evolved group I intron spliceozymes by decreased side product formation.Semantic proximity Read ↗

The conserved terminal guanosine of a group I intron can help prevent reopening of the ligated exons.Semantic proximity Read ↗

Base pairing between the 3' exon and an internal guide sequence increases 3' splice site specificity in the Tetrahymena self-splicing rRNA intron.Semantic proximity Read ↗

A base triple in the Tetrahymena group I core affects the reaction equilibrium via a threshold effect.Semantic proximity Read ↗

Sequence specificity of in vivo reverse splicing of the Tetrahymena group I intron.Semantic proximity Read ↗

New loop-loop tertiary interactions in self-splicing introns of subgroup IC and ID: a complete 3D model of the Tetrahymena thermophila ribozyme.Semantic proximity Read ↗

Group I-like ribozymes with a novel core organization perform obligate sequential hydrolytic cleavages at two processing sites.Semantic proximity Read ↗

Transitions between the steps of forward and reverse splicing of group IIC introns.Semantic proximity Read ↗

The spliceosome catalyzes debranching in competition with reverse of the first chemical reaction.Semantic proximity Read ↗

G triplets located throughout a class of small vertebrate introns enforce intron borders and regulate splice site selection.Semantic proximity Read ↗

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