Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel function for the U2AF 65 splicing factor in promoting pre-mRNA 3'-end processing.

EMBO reports - 1 Sept 2002

Millevoi Stefania, Geraghty Finola, Idowu Bernadine, Tam Jennifer L Y, Antoniou Michael, Vagner Stéphan

Abstract excerpt

Splicing and 3'-end processing (including cleavage and polyadenylation) of vertebrate pre-mRNAs are tightly coupled events that contribute to the extensive molecular network that coordinates gene expression. Sequences within the terminal intron of genes are essential to stimulate pre-mRNA 3'-end processing, although the factors mediating this effect are unknown. Here, we show that the pyrimidine tract of the last...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta-Thalassemia
Share to Precipitin Tests

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Pyrimidines

Share to Ribonucleoproteins

Share to RNA Splicing

Share to Single-Strand Specific DNA and RNA Endonucleases

Share to Splicing Factor U2AF

Share to Ultraviolet Rays

Source

Open in PubMed Open full text

Identifiers

PMID: 12189174
DOI: 10.1093/embo-reports/kvf173
PMCID: PMC1084226

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel function for the U2AF 65 splicing factor in promoting pre-mRNA 3'-end processing.PMID 12189174Read ↗

Structure-guided U2AF65 variant improves recognition and splicing of a defective pre-mRNA.Semantic proximity Read ↗

Splicing factors stimulate polyadenylation via USEs at non-canonical 3' end formation signals.Semantic proximity Read ↗

Intron removal requires proofreading of U2AF/3' splice site recognition by DEK.Semantic proximity Read ↗

Mechanisms for U2AF to define 3' splice sites and regulate alternative splicing in the human genome.Semantic proximity Read ↗

Multi-domain conformational selection underlies pre-mRNA splicing regulation by U2AF.Semantic proximity Read ↗

RBBP6 activates the pre-mRNA 3’-end processing machinery in humansSemantic proximity Read ↗

The role of U2AF35 and U2AF65 in enhancer-dependent splicing.Semantic proximity Read ↗

AG-dependent 3'-splice sites are predisposed to aberrant splicing due to a mutation at the first nucleotide of an exon.Semantic proximity Read ↗

Pre-mRNA Splicing Factor U2AF2 Recognizes Distinct Conformations of Nucleotide Variants at the Center of the pre-mRNA Splice Site SignalSemantic proximity Read ↗

Structuring of the 3' splice site by U2AF65.Semantic proximity Read ↗

Upstream Elements Present in the 3′-Untranslated Region of Collagen Genes Influence the Processing Efficiency of Overlapping Polyadenylation SignalsSemantic proximity Read ↗

An intronic splicing enhancer binds U1 snRNPs to enhance splicing and select 5' splice sites.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.