Article
A tertiary interaction that links active-site domains to the 5' splice site of a group II intron.
Nature - 20 Jul 2000
Boudvillain M, de Lencastre A, Pyle A M
Abstract excerpt
Group II introns are self-splicing RNAs that are commonly found in the genes of plants, fungi, yeast and bacteria. Little is known about the tertiary structure of group II introns, which are among the largest natural ribozymes. The most conserved region of the intron is domain 5 (D5), which, together with domain 1 (D1), is required for all reactions catalysed by the intron. Despite the importance of D5, its...
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