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Article

Invariant U2 snRNA nucleotides form a stem loop to recognize the intron early in splicing.

Molecular cell - 14 May 2010

Perriman Rhonda, Ares Manuel

Abstract excerpt

U2 snRNA-intron branchpoint pairing is a critical step in pre-mRNA recognition by the splicing apparatus, but the mechanism by which these two RNAs engage each other is unknown. Here, we identify a U2 snRNA structure, the branchpoint-interacting stem loop (BSL), which presents the U2 nucleotides that will contact the intron. We provide evidence that the BSL forms prior to interaction with the intron and is...

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Identifiers

PMID: 20471947
DOI: 10.1016/j.molcel.2010.02.036
PMCID: PMC2872779

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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