Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Length changes in the joining segment between domains 5 and 6 of a group II intron inhibit self-splicing and alter 3' splice site selection.

Molecular and cellular biology - 1 Oct 1996

Boulanger S C, Faix P H, Yang H, Zhuo J, Franzen J S, Peebles C L, Perlman P S

Abstract excerpt

Domain 5 (D5) and domain 6 (D6) are adjacent folded hairpin substructures of self-splicing group II introns that appear to interact within the active ribozyme. Here we describe the effects of changing the length of the 3-nucleotide segment joining D5 to D6 [called J(56)3] on the splicing reactions of intron 5 gamma of the COXI gene of yeast mitochondrial DNA. Shortened variants J(56)0 and J(56)1 were defective in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to DNA, Fungal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA, Mitochondrial

Share to Genetic Variation

Share to Molecular Sequence Data

Share to Plasmids

Share to Saccharomyces cerevisiae

Share to Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 8816503
DOI: 10.1128/MCB.16.10.5896
PMCID: PMC231591

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Length changes in the joining segment between domains 5 and 6 of a group II intron inhibit self-splicing and alter 3' splice site selection.PMID 8816503Read ↗

Studies of point mutants define three essential paired nucleotides in the domain 5 substructure of a group II intron.Semantic proximity Read ↗

Mutations of the two-nucleotide bulge of D5 of a group II intron block splicing in vitro and in vivo: phenotypes and suppressor mutations.Semantic proximity Read ↗

Control of branch-site choice by a group II intron.Semantic proximity Read ↗

The splicing of yeast mitochondrial group I and group II introns requires a DEAD-box protein with RNA chaperone function.Semantic proximity Read ↗

Intron 5 alpha of the COXI gene of yeast mitochondrial DNA is a mobile group I intron.Semantic proximity Read ↗

Self-splicing of a Podospora anserina group IIA intron in vitro. Effects of 3'-terminal intron alterations on cleavage at the 5' and 3' splice site.Semantic proximity Read ↗

The mobile group I intron 3 alpha of the yeast mitochondrial COXI gene encodes a 35-kDa processed protein that is an endonuclease but not a maturase.Semantic proximity Read ↗

Splicing defective mutants of the COXI gene of yeast mitochondrial DNA: initial definition of the maturase domain of the group II intron aI2.Semantic proximity Read ↗

Interactions of the yeast U6 RNA with the pre-mRNA branch site.Semantic proximity Read ↗

Domain 5 binds near a highly conserved dinucleotide in the joiner linking domains 2 and 3 of a group II intron.Semantic proximity Read ↗

A tertiary interaction that links active-site domains to the 5' splice site of a group II intron.Semantic proximity Read ↗

Evidence that U2/U6 helix I promotes both catalytic steps of pre-mRNA splicing and rearranges in between these steps.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.