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Article

New loop-loop tertiary interactions in self-splicing introns of subgroup IC and ID: a complete 3D model of the Tetrahymena thermophila ribozyme.

Chemistry & biology - 1 Dec 1996

Lehnert V, Jaeger L, Michel F, Westhof E

Abstract excerpt

BACKGROUND: Group I introns self-splice via two consecutive trans-esterification reactions in the presence of guanosine cofactor and magnesium ions. Comparative sequence analysis has established that a catalytic core of about 120 nucleotides is conserved in all known group I introns. This core is generally not sufficient for activity, however, and most self-splicing group I introns require non-conserved...

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Identifiers

PMID: 9000010
DOI: 10.1016/s1074-5521(96)90166-0

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