Article
A 3' splice site-binding sequence in the catalytic core of a group I intron.
Nature - 1 Mar 1990
Burke J M, Esherick J S, Burfeind W R, King J L
Abstract excerpt
Ribozymes use specific RNA-RNA interactions for substrate binding and active-site formation. Self-splicing group I introns have approximately 70 nucleotides constituting the core, a region containing sequences and structures indispensable for catalytic function. The catalytic core must interact with the substrates used for the two steps of the self-splicing reaction, that is, guanosine, the 5'-splice-site helix...
Topics
- Animals
- Base Sequence
- Catalysis
- Introns
- Magnesium
- Models, Genetic
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- RNA Precursors
- RNA Splicing
- RNA, Catalytic