Article
A conserved element that stabilizes the group II intron active site.
RNA (New York, N.Y.) - 1 Jun 2008
Fedorova Olga, Pyle Anna Marie
Abstract excerpt
The internal loop at the base of domain 3 (D3) is one of the most conserved and catalytically important elements of a group II intron. However, the location and molecular nature of its tertiary interaction partners has remained unknown. By employing a combination of site-directed photo-cross-linking and nucleotide analog interference suppression (NAIS), we show that the domain 3 internal loop (D3IL) interacts...
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