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Article

Characterization of prokaryotic recombinant Aspergillus ribotoxin alpha-sarcin.

Biochimica et biophysica acta - 21 Aug 1997

Sylvester I D, Roberts L M, Lord J M

Abstract excerpt

The Aspergillus ribonuclease alpha-sarcin is toxic to intact mammalian cells but the mechanism by which it enters the cells to reach its ribosomal RNA substrate is unclear. Here we have compared the cytotoxicity of alpha-sarcin to that of ricin, another catalytic toxin that targets the same rRNA sequence but whose mechanism of cell entry is better understood. Intact ricin binds to cell surface components and...

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PMID: 9296521
DOI: 10.1016/s0167-4889(97)00048-7

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