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Article

Modification of ricin A chain, by addition of endoplasmic reticulum (KDEL) or Golgi (YQRL) retention sequences, enhances its cytotoxicity and translocation.

Cancer immunology, immunotherapy : CII - 1 Mar 1998

Zhan J, Stayton P, Press O W

Abstract excerpt

A pKK expression system in Escherichia coli was used to produce recombinant ricin A chain (rRTA) and rRTA modified by addition of organelle-specific amino acid retention sequences, including KDEL (an endoplasmic reticulum, ER, lumen retention signal), KKMP (an ER membrane retention signal), YQRL (a trans-Golgi network retention signal) and KFERQ (a lysosome-targeting signal) to the C terminus of rRTA. The...

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Identifiers

PMID: 9520293
DOI: 10.1007/s002620050460
PMCID: PMC11037320

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Source receipt: pubmed, retrieved 7 Sept 2026.

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