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Article

Saporin and ricin A chain follow different intracellular routes to enter the cytosol of intoxicated cells.

The FEBS journal - 1 Oct 2005

Vago Riccardo, Marsden Catherine J, Lord J Michael, Ippoliti Rodolfo, Flavell David J, Flavell Sopsamorn-U, Ceriotti Aldo, Fabbrini M Serena

Abstract excerpt

Several protein toxins, such as the potent plant toxin ricin, enter mammalian cells by endocytosis and undergo retrograde transport via the Golgi complex to reach the endoplasmic reticulum (ER). In this compartment the catalytic moieties exploit the ER-associated degradation (ERAD) pathway to reach their cytosolic targets. Bacterial toxins such as cholera toxin or Pseudomonas exotoxin A carry KDEL or KDEL-like...

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Identifiers

PMID: 16176271
DOI: 10.1111/j.1742-4658.2005.04908.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Saporin and ricin A chain follow different intracellular routes to enter the cytosol of intoxicated cells.PMID 16176271Read ↗

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