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Article

A non-cytotoxic but ribonucleolytically specific ribotoxin variant: implication of tryptophan residues in the cytotoxicity of hirsutellin A.

Biological chemistry - 1 May 2012

Herrero-Galán Elías, García-Ortega Lucía, Lacadena Javier, Martínez-del-Pozo Álvaro, Olmo Nieves, Gavilanes José G, Oñaderra Mercedes

Abstract excerpt

Ribotoxins are a family of toxic proteins that exert a highly specific cleavage at the universally conserved sarcin/ricin loop (SRL) of the larger rRNA molecule. Before this ribonucleolytic action, passage through the cell membrane is a necessary step for ribotoxin internalization and the limiting factor for cytotoxicity. Although extensive knowledge of their ribonucleolytic activity and substrate recognition has...

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Source

Identifiers

PMID: 22628308
DOI: 10.1515/hsz-2011-0278

Genes

SRL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A non-cytotoxic but ribonucleolytically specific ribotoxin variant: implication of tryptophan residues in the cytotoxicity of hirsutellin A.PMID 22628308Read ↗

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