Article
Ricin A chain utilises the endoplasmic reticulum-associated protein degradation pathway to enter the cytosol of yeast.
FEBS letters - 1 Oct 1999
Simpson J C, Roberts L M, Römisch K, Davey J, Wolf D H, Lord J M
Abstract excerpt
Cytotoxic proteins such as ricin A chain (RTA) have target substrates in the cytosol and therefore have to reach this cellular compartment in order to act. RTA is thought to translocate into the cytosol from the lumen of the endoplasmic reticulum (ER), although how it traverses the ER membrane has not been established. Using yeast mutants defective in various aspects of the ER-associated protein degradation...
Topics
- Biological Transport
- Cysteine Endopeptidases
- Cytosol
- Endoplasmic Reticulum
- Membrane Proteins
- Membrane Transport Proteins
- Multienzyme Complexes
- Mutation
- Peptide Hydrolases
- Proteasome Endopeptidase Complex
- Ricin
- SEC Translocation Channels
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins