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Article

Mutational analysis of the Shiga toxin and Shiga-like toxin II enzymatic subunits.

Journal of bacteriology - 1 Jun 1990

Jackson M P, Deresiewicz R L, Calderwood S B

Abstract excerpt

The A-subunit polypeptides of Shiga toxin, the Shiga-like toxins (SLTs), and the plant lectin ricin inactivate eucaryotic ribosomes by enzymatically depurinating 28S rRNA. Comparison of the amino acid sequences of the members of the Shiga toxin family and ricin revealed two regions of significant homology that lie within a proposed active-site cleft of the ricin A chain. In previous studies, these conserved...

Topics

Amino Acid Sequence
Bacterial Toxins
Binding Sites
Enterotoxins
Mutation
Shiga Toxin 2
Shiga Toxins

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 2345150
DOI: 10.1128/jb.172.6.3346-3350.1990
PMCID: PMC209145

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2345150-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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