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Article

Ricin inhibits activation of the unfolded protein response by preventing splicing of the HAC1 mRNA.

The Journal of biological chemistry - 7 Mar 2008

Parikh Bijal A, Tortora Andrew, Li Xiao-Ping, Tumer Nilgun E

Abstract excerpt

Ricin A chain (RTA) inhibits protein synthesis by removing a specific adenine from the highly conserved alpha-sarcin/ricin loop in the large rRNA. Expression of RTA with its own signal sequence in yeast resulted in its translocation into the endoplasmic reticulum (ER) and subsequent glycosylation. Because RTA must unfold within the ER, it may be vulnerable to host defenses, such as the unfolded protein response...

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Identifiers

PMID: 18180297
DOI: 10.1074/jbc.M707981200
PMCID: PMC3024914

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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