Article
Free ricin A chain reaches an early compartment of the secretory pathway before it enters the cytosol.
Experimental cell research - 15 Dec 1996
Simpson J C, Roberts L M, Lord J M
Abstract excerpt
During the intoxication of mammalian cells by ricin, the catalytically active A chain must cross the membrane of an intracellular compartment in order to reach its ribosomal substrates in the cytosol. The actual site of ricin A chain translocation is unclear, and conflicting views hold that it en...
Topics
- Amino Acid Sequence
- Biological Transport, Active
- Brefeldin A
- Cell Compartmentation
- Cyclopentanes
- Cytosol
- GTP Phosphohydrolases
- HeLa Cells
- Humans
- Mutation
- Protein Synthesis Inhibitors
- Ricin