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Article

Dependence of ricin toxicity on translocation of the toxin A-chain from the endoplasmic reticulum to the cytosol.

The Journal of biological chemistry - 26 Nov 1999

Wesche J, Rapak A, Olsnes S

Abstract excerpt

Ricin acts by translocating to the cytosol the enzymatically active toxin A-chain, which inactivates ribosomes. Retrograde intracellular transport and translocation of ricin was studied under conditions that alter the sensitivity of cells to the toxin. For this purpose tyrosine sulfation of mutant A-chain in the Golgi apparatus, glycosylation in the endoplasmic reticulum (ER) and appearance of A-chain in the...

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PMID: 10567425
DOI: 10.1074/jbc.274.48.34443

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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