Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Infrequency of BRCA2 alterations in head and neck squamous cell carcinoma.

Oncogene - 8 May 1997

Kirkpatrick H, Waber P, Hoa-Thai T, Barnes R, Osborne-Lawrence S, Truelson J, Nisen P, Bowcock A

Abstract excerpt

Alterations of BRCA2 result in increased susceptibility to breast cancer in both men and women (relative lifetime risks of 0.06 and 0.8 respectively). BRCA2 maps to 13q12-q13 and encodes a transcript of 10,157 bp. Other cancers that have been described in BRCA2 mutation carriers include those of the larynx. Human chromosome 13q has been shown previously by LOH studies to harbor several tumor suppressor genes for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Alleles
Share to Gene Frequency

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Heterozygote

Share to Microsatellite Repeats

Share to Mutation

Share to Neoplasm Proteins

Share to Polymorphism, Genetic

Source

Identifiers

PMID: 9174054
DOI: 10.1038/sj.onc.1201060

Genes

BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Infrequency of BRCA2 alterations in head and neck squamous cell carcinoma.PMID 9174054Read ↗

Distinct regions of loss of heterozygosity on 22q in different sites of head and neck squamous cell carcinomas.Semantic proximity Read ↗

Allelic loss at chromosomes 3p, 8p, 13q, and 17p associated with poor prognosis in head and neck cancer.Semantic proximity Read ↗

Loss of heterozygosity in sporadic breast tumours at the BRCA2 locus on chromosome 13q12-q13.Semantic proximity Read ↗

Multiple tumor-suppressor genes on chromosome 3p contribute to head and neck squamous cell carcinoma tumorigenesis.Semantic proximity Read ↗

Patterns of loss of heterozygosity at loci from chromosome arm 13q suggests a possible involvement of BRCA2 in sporadic breast tumors.Semantic proximity Read ↗

Multiple squamous cell carcinomas of the head and neck show different phenotypes of allelic loss patterns suggesting different clonal origin of carcinogenesis.Semantic proximity Read ↗

Infrequent mutation in the BRCA2 gene in esophageal squamous cell carcinoma.Semantic proximity Read ↗

Multiple regions of deletion on chromosome arm 13q in head-and-neck squamous-cell carcinoma.Semantic proximity Read ↗

Identification of distinct regions of allelic loss on chromosome 13q in nasopharyngeal cancer from paraffin embedded tissues.Semantic proximity Read ↗

HPV-associated cervical cancers show frequent allelic loss at 3p14 but no apparent aberration of FHIT mRNA.Semantic proximity Read ↗

Consistent loss of the wild type allele in breast cancers from a family linked to the BRCA2 gene on chromosome 13q12-13.Semantic proximity Read ↗

Lymph node metastasis is associated with allelic loss on chromosome 13q12-13 in esophageal squamous cell carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.