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Article

Patterns of loss of heterozygosity at loci from chromosome arm 13q suggests a possible involvement of BRCA2 in sporadic breast tumors.

Genes, chromosomes & cancer - 1 Aug 1995

Kerangueven F, Allione F, Noguchi T, Adélaïde J, Sobol H, Jacquemier J, Birnbaum D

Abstract excerpt

Loss of heterozygosity (LOH) at loci from chromosome 13 is frequently observed in breast cancer. Chromosome 13 contains at least two cancer genes, the well-characterized RB1 gene located at 13q14 and the breast cancer-susceptibility gene, BRCA2, recently localized to 13q12. To investigate the possible involvement of BRCA2 in sporadic breast tumors, we looked at LOH at eight microsatellite (CA)n markers...

Topics

Alleles
BRCA2 Protein
Breast Neoplasms
Chromosome Deletion
Chromosome Mapping
Chromosomes, Human, Pair 13
Female
Genetic Markers
Humans
Microsatellite Repeats
Neoplasm Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Retinoblastoma Protein

Transcription Factors

Source

Identifiers

PMID: 7547638
DOI: 10.1002/gcc.2870130410

Genes

BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7547638-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Patterns of loss of heterozygosity at loci from chromosome arm 13q suggests a possible involvement of BRCA2 in sporadic breast tumors.PMID 7547638Read ↗

Loss of heterozygosity in sporadic breast tumours at the BRCA2 locus on chromosome 13q12-q13.Semantic proximity Read ↗

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