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Article

Infrequent mutation in the BRCA2 gene in esophageal squamous cell carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2002

Hu Nan, Li Guang, Li Wen-Jun, Wang Chaoyu, Goldstein Alisa M, Tang Ze-Zhong, Roth Mark J, Dawsey Sanford M, Huang Jing, Wang Quan-Hong, Ding Ti, Giffen Carol, Taylor Philip R, Emmert-Buck Michael R

Abstract excerpt

PURPOSE: Previous studies have shown a high rate of allelic loss in esophageal squamous cell carcinoma (ESCC) in the vicinity of the BRCA2 gene. We aimed to assess whether the tumor suppressor gene BRCA2 was the inactivation target for allelic loss observed on chromosome 13q in ESCC. EXPERIMENTAL DESIGN: We examined the entire coding sequence of the BRCA2 gene for mutations using single-strand conformation...

Read the complete abstract on PubMed

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Share to BRCA2 Protein
Share to Carcinoma, Squamous Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 13

Share to DNA, Neoplasm

Share to Esophageal Neoplasms

Share to Family Health

Share to Loss of Heterozygosity

Share to Polymorphism, Single-Stranded Conformational

Source

Identifiers

PMID: 11948123

Genes

BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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