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Article

Loss of heterozygosity in sporadic breast tumours at the BRCA2 locus on chromosome 13q12-q13.

British journal of cancer - 1 Nov 1995

Cleton-Jansen A M, Collins N, Lakhani S R, Weissenbach J, Devilee P, Cornelisse C J, Stratton M R

Abstract excerpt

Loss of heterozygosity (LOH) on chromosome 13 occurs on 25-30% of breast tumours. This may reflect the inactivation of the retinoblastoma susceptibility gene RB1. However, recently another candidate tumour-suppressor gene has been identified on chromosome 13 by linkage analysis, the breast cancer susceptibility gene BRCA2. To investigate the involvement of BRCA2 in sporadic breast cancer 200 breast tumours were...

Topics

Alleles
BRCA2 Protein
Breast Neoplasms
Chromosomes, Human, Pair 13
Female
Gene Deletion
Genes, Retinoblastoma
Genetic Linkage
Humans
Microsatellite Repeats
Neoplasm Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oncogenes

Polymorphism, Genetic

Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 7577475
DOI: 10.1038/bjc.1995.493
PMCID: PMC2033960

Genes

BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7577475-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Loss of heterozygosity in sporadic breast tumours at the BRCA2 locus on chromosome 13q12-q13.PMID 7577475Read ↗

Patterns of loss of heterozygosity at loci from chromosome arm 13q suggests a possible involvement of BRCA2 in sporadic breast tumors.Semantic proximity Read ↗

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