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Article

Consistent loss of the wild type allele in breast cancers from a family linked to the BRCA2 gene on chromosome 13q12-13.

Oncogene - 20 Apr 1995

Collins N, McManus R, Wooster R, Mangion J, Seal S, Lakhani S R, Ormiston W, Daly P A, Ford D, Easton D F

Abstract excerpt

A small proportion of breast cancer is attributable to the inheritance of dominant, high penetrance susceptibility genes. One of these genes, BRCA2, has recently been localised by genetic linkage analysis to chromosome 13q12-13. This is a region known to exhibit loss of heterozygosity in 20-40% sporadic breast cancers. In this study, we have examined cancers from a family showing strong evidence of linkage to...

Topics

Alleles
BRCA2 Protein
Breast Neoplasms
Chromosome Deletion
Chromosomes, Human, Pair 13
Female
Genes, Tumor Suppressor
Genetic Linkage
Humans
Neoplasm Proteins
Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 7731724

Genes

BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7731724-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Consistent loss of the wild type allele in breast cancers from a family linked to the BRCA2 gene on chromosome 13q12-13.PMID 7731724Read ↗

Loss of heterozygosity in sporadic breast tumours at the BRCA2 locus on chromosome 13q12-q13.Semantic proximity Read ↗

Patterns of loss of heterozygosity at loci from chromosome arm 13q suggests a possible involvement of BRCA2 in sporadic breast tumors.Semantic proximity Read ↗

Allelic loss at chromosome 13q12-q13 is associated with poor prognosis in familial and sporadic breast cancer.Semantic proximity Read ↗

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Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13.Semantic proximity Read ↗

Identification of the breast cancer susceptibility gene BRCA2.Semantic proximity Read ↗

The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds.Semantic proximity Read ↗

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