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Article

HPV-associated cervical cancers show frequent allelic loss at 3p14 but no apparent aberration of FHIT mRNA.

International journal of cancer - 19 Jan 1998

Chu T Y, Shen C Y, Chiou Y S, Lu J J, Perng C L, Yu M S, Liu H S

Abstract excerpt

The genetic aberration involved in the loss of heterozygosity (LOH) at 3p14 has recently been attributed to the disruption of the FHIT gene in many cancers. This study analyzed HPV DNA and allelic status of 5 microsatellite markers spaning 3p13-3p25 in 57 cases of cervical cancer. With no homozygous deletion found in any case, a 39% overall frequency of LOH was noted. The presence of tumorigenic HPV DNA (91%) did...

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Source

Identifiers

PMID: 9462708
DOI: 10.1002/(sici)1097-0215(19980119)75:2<199::aid-ijc6>3.0.co;2-p

Genes

FHIT
THRB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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HPV-associated cervical cancers show frequent allelic loss at 3p14 but no apparent aberration of FHIT mRNA.PMID 9462708Read ↗

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Deletions of chromosome 3p are frequent and early events in the pathogenesis of uterine cervical carcinoma.Semantic proximity Read ↗

High resolution analysis of chromosome 3p alterations in cervical carcinoma.Semantic proximity Read ↗

PCR-RFLP studies on chromosome 3p in formaldehyde-fixed, paraffin-embedded cervical cancer tissues.Semantic proximity Read ↗

Frequent allelic deletion at the FHIT locus associated with p53 overexpression in squamous cell carcinoma subtype of Taiwanese non-small-cell lung cancers.Semantic proximity Read ↗

FHIT and FRA3B 3p14.2 allele loss are common in lung cancer and preneoplastic bronchial lesions and are associated with cancer-related FHIT cDNA splicing aberrations.Semantic proximity Read ↗

Cervical intraepithelial neoplasia III shows frequent allelic loss in 3p and 6p.Semantic proximity Read ↗

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