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Article

A persistent double-strand break destabilizes human DNA in yeast and can lead to G2 arrest and lethality.

Cancer research - 15 May 1997

Bennett C B, Snipe J R, Resnick M A

Abstract excerpt

Double-strand breaks (DSBs) are an important source of genomic change in many organisms. We have examined the consequences of a persistent versus a rapidly repaired DSB on cell progression, viability, and stability of human DNA contained in dispensable yeast artificial chromosomes (YACs) within the yeast Saccharomyces cerevisiae. An Alu-URA3-YZ integrating plasmid was used to target the YZ sequence to repetitive...

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PMID: 9157993

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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