Article
Persistent broken chromosome inheritance drives genome instability
2020-08-27
Abstract excerpt
Persistent DNA damage arising from unrepaired broken chromosomes or telomere loss can promote DNA damage checkpoint adaptation, and cell cycle progression, thereby increasing cell survival but also genome instability. However, the nature and extent of such instability is unclear. We show, using Schizosaccharomyces pombe , that inherited broken chromosomes, arising from failed homologous recombination repair, are...
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Identifiers and source
- Literature Corpus work
- 26fd3899-4b50-5fa5-aa23-676a3d86d57b
- DOI
- 10.1101/2020.08.26.268565