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Article

Reduced levels of DNA polymerase delta induce chromosome fragile site instability in yeast.

Molecular and cellular biology - 1 Sept 2008

Lemoine Francene J, Degtyareva Natasha P, Kokoska Robert J, Petes Thomas D

Abstract excerpt

Specific regions of genomes (fragile sites) are hot spots for the chromosome rearrangements that are associated with many types of cancer cells. Understanding the molecular mechanisms regulating the stability of chromosome fragile sites, therefore, has important implications in cancer biology. We previously identified two chromosome fragile sites in Saccharomyces cerevisiae that were induced in response to the...

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Identifiers

PMID: 18591249
DOI: 10.1128/MCB.02084-07
PMCID: PMC2519721

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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