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Article

Maintenance of genome stability in Saccharomyces cerevisiae.

Science (New York, N.Y.) - 26 Jul 2002

Kolodner Richard D, Putnam Christopher D, Myung Kyungjae

Abstract excerpt

Most human cancer cells show signs of genome instability, ranging from elevated mutation rates to gross chromosomal rearrangements and alterations in chromosome number. Little is known about the molecular mechanisms that generate this instability or how it is suppressed in normal cells. Recent studies of the yeast Saccharomyces cerevisiae have begun to uncover the extensive and redundant pathways that keep the...

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PMID: 12142524
DOI: 10.1126/science.1075277

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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