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Chromosomal aberrations induced by double strand DNA breaks.

DNA repair - 15 Aug 2005

Varga Tamas, Aplan Peter D

Abstract excerpt

It has been suggested that introduction of double strand DNA breaks (DSBs) into mammalian chromosomes can lead to gross chromosomal rearrangements through improper DNA repair. To study this phenomenon, we employed a model system in which a double strand DNA break can be produced in human cells in vivo at a predetermined location. The ensuing chromosomal changes flanking the breakage site can then be cloned and...

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Identifiers

PMID: 15935739
DOI: 10.1016/j.dnarep.2005.05.004
PMCID: PMC1237002

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