Saccharomyces cerevisiae linear chromosome stability (lcs) mutants increase the loss rate of artificial and natural linear chromosomes.

doi:10.1007/BF00387735

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Article

Saccharomyces cerevisiae linear chromosome stability (lcs) mutants increase the loss rate of artificial and natural linear chromosomes.

Chromosoma - 1 Feb 1993

Runge K W, Zakian V A

Abstract excerpt

We isolated mutants of Saccharomyces cerevisiae that lose a 100 kb linear yeast artificial chromosome (YAC) at elevated rates. Mutations in two of these LCS (linear chromosome stability) genes had little or no effect on the loss rate of a circular YAC that had the same centromere and origin of re...

Topics

Chromosomes, Fungal
DNA, Fungal
Genes, Fungal
Genetic Complementation Test
Mutation
Repetitive Sequences, Nucleic Acid
Saccharomyces cerevisiae
Telomere

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