Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrity of human YACs during propagation in recombination-deficient yeast strains.

Genomics - 15 Mar 1999

Kouprina N, Nikolaishvili N, Graves J, Koriabine M, Resnick M A, Larionov V

Abstract excerpt

Several isogenic strains with defects in recombination/repair genes (RAD1, RAD50, RAD51, RAD52, RAD54, and RAD55) were examined for their ability to propagate accurately a variety of linear and circular yeast artificial chromosomes (YACs) containing human DNA inserts. To assess YAC stability, the human DNA inserts were internally marked by an ADE2-pBR-URA3 cassette. Following selection for Ura- clones on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Artificial, Yeast
Share to DNA Repair Enzymes
Share to Endonucleases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Galactose

Share to Rad51 Recombinase

Share to Rad52 DNA Repair and Recombination Protein

Share to Transformation, Genetic

Share to Yeasts

Source

Identifiers

PMID: 10087193
DOI: 10.1006/geno.1998.5727

Genes

RAD52
RAD1
RAD50
RAD51

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrity of human YACs during propagation in recombination-deficient yeast strains.PMID 10087193Read ↗

Stabilization of yeast artificial chromosome clones in a rad54-3 recombination-deficient host strain.Semantic proximity Read ↗

Construction of a pilot human YAC library in a recombination-defective yeast strain.Semantic proximity Read ↗

Construction and characterization of a rad51rad52 double mutant as a host for YAC libraries.Semantic proximity Read ↗

Genetic control of intrachromosomal recombination.Semantic proximity Read ↗

A persistent double-strand break destabilizes human DNA in yeast and can lead to G2 arrest and lethality.Semantic proximity Read ↗

Protecting genomic integrity in somatic cells and embryonic stem cells.Semantic proximity Read ↗

Intrachromosomal Recombination in Yeast.Semantic proximity Read ↗

Differential Requirements for the RAD51 Paralogs in Genome Repair and Maintenance in Human CellsSemantic proximity Read ↗

The role of recombination and RAD52 in mutation of chromosomal DNA transformed into yeast.Semantic proximity Read ↗

Inverted Alu repeats unstable in yeast are excluded from the human genome.Semantic proximity Read ↗

The homologous recombination protein RAD51D protects the genome from large deletions.Semantic proximity Read ↗

Comparison of Two Budding Yeast Disome Model Systems: Similarities, Difference, and ConflictSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.