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Article

Inverted Alu repeats unstable in yeast are excluded from the human genome.

The EMBO journal - 17 Jul 2000

Lobachev K S, Stenger J E, Kozyreva O G, Jurka J, Gordenin D A, Resnick M A

Abstract excerpt

The nearly one million ALU: repeats in human chromosomes are a potential threat to genome integrity. ALU:s form dense clusters where they frequently appear as inverted repeats, a sequence motif known to cause DNA rearrangements in model organisms. Using a yeast recombination system, we found that inverted ALU: pairs can be strong initiators of genetic instability. The highly recombinagenic potential of inverted...

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Identifiers

PMID: 10899135
DOI: 10.1093/emboj/19.14.3822
PMCID: PMC313988

Genes

FEN1
MMS19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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